The shutdown of the HIV research at a National Institutes of Health laboratory in Montana, first reported in Science, was never disclosed publicly by government officials, who have forbidden affected researchers from discussing what happened.

The Trump administration shut down a government-run study, which uses fetal tissue implanted into mice, even before federal health officials reach a decision on whether to continue such research, which is opposed by antiabortion groups.

A senior scientist at a the Montana lab told colleagues that the Health and Human Services Department “has directed me to discontinue procuring fetal tissue” from a firm that is the only available source, according to an email he sent to a collaborator in late September.

“This effectively stops all of our research to discover a cure for HIV,” the researcher wrote.

The disruptions might extend to a handful of other labs using fetal tissue, all of which are part of NIH, rather than outside research institutions operating on NIH grants, according to an individual familiar with the situation.

Outcry from the scientific community

Colleagues say they are incensed by the action, which has fanned a controversy that pits the biomedical research community against antiabortion activists and other social conservatives pressing the administration to stop the flow of federal grants and contracts for work involving fetal tissue. Such tissue comes from elective abortions.

“This is scientific censorship of the worst kind,” said Warner Greene, who was director of the Gladstone Institute of Virology and Immunology for a quarter century since its founding in 1991 and now runs an HIV research lab there. He was poised to collaborate with the Montana researcher, Kim Hasenkrug, on a new experiment that has been thwarted.

“You spend your life trying to do good experiments and organize your science carefully,” Greene said, “and suddenly, at the whim of some politicians in Washington, D.C., they remove a critical piece of your scientific armamentarium.”

Hasenkrug was not available for comment. Greene and Irving Weissman, a pioneer in stem cell research at Stanford University, said government officials imposed a gag order on him.

An NIH spokeswoman said that when HHS began its review of fetal tissue in September, the NIH put in place a “pause” in the procurement of that kind of tissue. Researchers were instructed to notify top officials if they needed more. The spokeswoman said the NIH is investigating why that didn’t happen with Hasenkrug’s research.

Thwarted research

News of the halted study broadens the actions the administration is known to have taken to obstruct such research. In late September, the HHS announced the termination of a Food and Drug Administration contract with a California firm, Advanced Bioscience Resources, and said it was conducting an “audit” of whether to keep funding fetal tissue research. An FDA notice in the summer of the pending contract called ABR “the only company in the U. S. capable of supplying tissues suitable for [humanized mouse] research.”

Then, in the past two weeks, a principal investigator at an academic laboratory in San Francisco was first told that a seven-year NIH contract was not being extended for its next year as usual. The university then received revised information that the lab was getting 90 days of funding, with the rest uncertain. The laboratory at the University of California at San Francisco is a linchpin in the development of new drugs to prevent and treat HIV, using mice implanted with human fetal tissue to run the first animal tests of chemical compounds developed by pharmaceutical companies and other academic scientists that seem promising in lab dishes.

Last week, HHS and NIH officials denied they had initially told the UCSF lab the contract was ending. The officials said that no decision would be made until HHS completes the audit of the government’s fetal tissue funding. The reconsideration is focused on examining whether adequate alternatives exist — as fetal tissue opponents contend and researchers dispute.

Officials are prepared to give 90-day extensions to other outside laboratories using fetal tissue whose grants or contracts come up for renewal before the audit is completed, according to an individual familiar with the research stoppage.

‘The rug was pulled out from underneath us’

Hasenkrug focuses on HIV and other persistent viruses at the Rocky Mountain Laboratories, part of the NIH’s National Institute of Allergy and Infectious Diseases. According to colleagues, he received a note from John J. McGowan, an NIAID deputy director, informing him the supply of fetal tissue for his research was being stopped. The note indicated that officials above McGowan had made the decision, without specifics. The money for Hasenkrug’s work comes from the NIH’s internal — or “intramural” — funds and is unrelated to the FDA contract that officials previously acknowledged they cut off, the colleagues said.

Greene said he and Hasenkrug have collaborated for several years and have previously used humanized mice to help demonstrate how T cells — immune cells that are diminished in HIV-infected people — die.

Greene said their labs were about to begin an experiment that would have been the first animal tests of an emerging theory about why HIV takes hold in the human body so quickly. Humanized mice are created by implanting fetal thymus tissue that can develop a humanlike immune system and be infected with HIV.

“The mice were ready,” Green said, “Just as we’d shipped antibody [to Montana], we were ready to go, and boom ... the rug was pulled out from underneath us.”

Alice Crites contributed to this report.

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